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Anti-Mouse MAG/Myelin-associated glycoprotein Polyclonal Antibody (MA497014)

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Aperçu
Numéro de catalogueMA497014
Description
Anti-Mouse MAG/Myelin-associated glycoprotein Polyclonal Antibody (MA497014) is a rabbit polyclonal antibody detecting MAG/Myelin-associated glycoprotein in ELISA, IHC, WB. Suitable for Rattus norvegicus, Human, and Mus musculus.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
  • ●Multi-Species — Cross-reactive for translational research.
Reactivité des espècesHuman, Mouse, Rat
ApplicationsELISA, IHC, WB
Espèce hôteRabbit
ClonalitéPolyclonal
IsotypeIgG
Immunogène E. coli - derived recombinant Mouse MAG/Myelin-associated glycoprotein (Asp235-Glu410).
Cible MAG/Myelin-associated glycoprotein
Purification Purified by antigen affinity column.
Numéro d'accès P20917
Forme Liquid
Tampon de stockage 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Informations d'utilisation du produit
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stabilité et stockage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Noms alternatifsMyelin-associated glycoprotein, Siglec-4a, Mag
Contexte

Myelin-associated glycoprotein (MAG) is a ~69 kDa protein. Adhesion molecule that mediates interactions between myelinating cells and neurons by binding to neuronal sialic acid-containing gangliosides and to the glycoproteins RTN4R and RTN4RL2. Not required for initial myelination, but seems to play a role in the maintenance of normal axon myelination. Protects motoneurons against apoptosis, also after injury; protection against apoptosis is probably mediated via interaction with neuronal RTN4R and RTN4RL2. Required to prevent degeneration of myelinated axons in adults; this probably depends on binding to gangliosides on the axon cell membrane. Negative regulator of neurite outgrowth that inhibits axon longitudinal growth.

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2. Pronker, MF. et al. (2016) Nature communications 7, 13584. PMID: 27922006
3. Kelm, S. et al. (1994) Current biology : CB 4, 965-72. PMID: 7533044
4. Schachner, M. et al. (2000) Glia 29, 154-65. PMID: 10625334
5. Li, C. et al. (1994) Nature 369, 747-50. PMID: 7516497
6. Bartsch, S. et al. (1997) Brain research 762, 231-4. PMID: 9262180
7. Li, C. et al. (1998) Journal of neuroscience research 51, 210-7. PMID: 9469574
8. Yin, X. et al. (1998) The Journal of neuroscience : the official journal of the Society for Neuroscience 18, 1953-62. PMID: 9482781
9. Fujita, N. et al. (1998) The Journal of neuroscience : the official journal of the Society for Neuroscience 18, 1970-8. PMID: 9482783
10. Palandri, A. et al. (2015) Cell death & disease 6, e1876. PMID: 26335717
Note For research use only.
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Formula
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C₂ (Working Conc.)
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Anti-Mouse MAG/Myelin-associated glycoprotein Polyclonal Antibody

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