Mouse MAG Recombinant Protein (C-Fc) (MB948021)

Name: Mouse MAG Recombinant Protein (C-Fc)
Brand: abinScience
SKU: MB948021
Price: 298 USD
Availability: InStock

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Overview

Catalog No.	MB948021
Description	Recombinant Mouse MAG Protein, C-Fc (MB948021) expressed in Mammalian Cells, spanning Met1-Pro516. Purity: >90% by SDS-PAGE. Highlights ●Fc Fusion — Enhanced stability with Protein A/G purification compatibility. ●Mammalian Expression — Proper folding and native glycosylation. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	Mammalian cells
Accession	P20917
Protein length	Met1-Pro516
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Mus musculus (Mouse)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	83.41 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	GMA, MAG, Myelin-associated glycoprotein, Siglec-4a
Background	Myelin-associated glycoprotein is a ~69 kDa protein. Adhesion molecule that mediates interactions between myelinating cells and neurons by binding to neuronal sialic acid-containing gangliosides and to the glycoproteins RTN4R and RTN4RL2. Not required for initial myelination, but seems to play a role in the maintenance of normal axon myelination. Protects motoneurons against apoptosis, also after injury; protection against apoptosis is probably mediated via interaction with neuronal RTN4R and RTN4RL2. Required to prevent degeneration of myelinated axons in adults; this probably depends on binding to gangliosides on the axon cell membrane. Negative regulator of neurite outgrowth that inhibits axon longitudinal growth. 1. Liu, BP. et al. (2002) Science (New York, N.Y.) 297, 1190-3. PMID: 12089450 2. Pronker, MF. et al. (2016) Nature communications 7, 13584. PMID: 27922006 3. Kelm, S. et al. (1994) Current biology : CB 4, 965-72. PMID: 7533044 4. Schachner, M. et al. (2000) Glia 29, 154-65. PMID: 10625334 5. Li, C. et al. (1994) Nature 369, 747-50. PMID: 7516497 6. Bartsch, S. et al. (1997) Brain research 762, 231-4. PMID: 9262180 7. Li, C. et al. (1998) Journal of neuroscience research 51, 210-7. PMID: 9469574 8. Yin, X. et al. (1998) The Journal of neuroscience : the official journal of the Society for Neuroscience 18, 1953-62. PMID: 9482781 9. Fujita, N. et al. (1998) The Journal of neuroscience : the official journal of the Society for Neuroscience 18, 1970-8. PMID: 9482783 10. Palandri, A. et al. (2015) Cell death & disease 6, e1876. PMID: 26335717
Note	For research use only

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Datasheet

Mouse MAG Recombinant Protein (C-Fc).pdf

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Mouse MAG Recombinant Protein (C-Fc) (MB948021)

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