Anti-Mouse MAG/Myelin-associated glycoprotein Polyclonal Antibody (MA497014)

Name: Anti-Mouse MAG/Myelin-associated glycoprotein Polyclonal Antibody
Brand: abinScience
SKU: MA497014
Price: 96 USD
Availability: InStock

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Overview

Catalog No.

MA497014

Description

Anti-Mouse MAG/Myelin-associated glycoprotein Polyclonal Antibody (MA497014) is a rabbit polyclonal antibody detecting MAG/Myelin-associated glycoprotein in ELISA, IHC, WB. Suitable for Rattus norvegicus, Human, and Mus musculus.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Species reactivity

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Mouse MAG/Myelin-associated glycoprotein (Asp235-Glu410).

Target

MAG/Myelin-associated glycoprotein

Purification

Purified by antigen affinity column.

Accession

P20917

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Alternate Names

Myelin-associated glycoprotein, Siglec-4a, Mag

Background

Myelin-associated glycoprotein (MAG) is a ~69 kDa protein. Adhesion molecule that mediates interactions between myelinating cells and neurons by binding to neuronal sialic acid-containing gangliosides and to the glycoproteins RTN4R and RTN4RL2. Not required for initial myelination, but seems to play a role in the maintenance of normal axon myelination. Protects motoneurons against apoptosis, also after injury; protection against apoptosis is probably mediated via interaction with neuronal RTN4R and RTN4RL2. Required to prevent degeneration of myelinated axons in adults; this probably depends on binding to gangliosides on the axon cell membrane. Negative regulator of neurite outgrowth that inhibits axon longitudinal growth.

1. Liu, BP. et al. (2002) Science (New York, N.Y.) 297, 1190-3. PMID: 12089450

2. Pronker, MF. et al. (2016) Nature communications 7, 13584. PMID: 27922006

3. Kelm, S. et al. (1994) Current biology : CB 4, 965-72. PMID: 7533044

4. Schachner, M. et al. (2000) Glia 29, 154-65. PMID: 10625334

5. Li, C. et al. (1994) Nature 369, 747-50. PMID: 7516497

6. Bartsch, S. et al. (1997) Brain research 762, 231-4. PMID: 9262180

7. Li, C. et al. (1998) Journal of neuroscience research 51, 210-7. PMID: 9469574

8. Yin, X. et al. (1998) The Journal of neuroscience : the official journal of the Society for Neuroscience 18, 1953-62. PMID: 9482781

9. Fujita, N. et al. (1998) The Journal of neuroscience : the official journal of the Society for Neuroscience 18, 1970-8. PMID: 9482783

10. Palandri, A. et al. (2015) Cell death & disease 6, e1876. PMID: 26335717

Note

For research use only.

Images

References

Datasheet

Anti-Mouse MAG/Myelin-associated glycoprotein Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

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Anti-Mouse MAG/Myelin-associated glycoprotein Polyclonal Antibody (MA497014)

Overview

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References

Datasheet

SDS

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