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| カタログ番号 | MA497014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Mouse MAG/Myelin-associated glycoprotein Polyclonal Antibody (MA497014) is a rabbit polyclonal antibody detecting MAG/Myelin-associated glycoprotein in ELISA, IHC, WB. Suitable for Rattus norvegicus, Human, and Mus musculus.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Mouse MAG/Myelin-associated glycoprotein (Asp235-Glu410). | ||||||||
| ターゲット | MAG/Myelin-associated glycoprotein | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P20917 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 別名 | Myelin-associated glycoprotein, Siglec-4a, Mag | ||||||||
| 背景 | Myelin-associated glycoprotein (MAG) is a ~69 kDa protein. Adhesion molecule that mediates interactions between myelinating cells and neurons by binding to neuronal sialic acid-containing gangliosides and to the glycoproteins RTN4R and RTN4RL2. Not required for initial myelination, but seems to play a role in the maintenance of normal axon myelination. Protects motoneurons against apoptosis, also after injury; protection against apoptosis is probably mediated via interaction with neuronal RTN4R and RTN4RL2. Required to prevent degeneration of myelinated axons in adults; this probably depends on binding to gangliosides on the axon cell membrane. Negative regulator of neurite outgrowth that inhibits axon longitudinal growth. 1. Liu, BP. et al. (2002) Science (New York, N.Y.) 297, 1190-3. PMID: 12089450 2. Pronker, MF. et al. (2016) Nature communications 7, 13584. PMID: 27922006 3. Kelm, S. et al. (1994) Current biology : CB 4, 965-72. PMID: 7533044 4. Schachner, M. et al. (2000) Glia 29, 154-65. PMID: 10625334 5. Li, C. et al. (1994) Nature 369, 747-50. PMID: 7516497 6. Bartsch, S. et al. (1997) Brain research 762, 231-4. PMID: 9262180 7. Li, C. et al. (1998) Journal of neuroscience research 51, 210-7. PMID: 9469574 8. Yin, X. et al. (1998) The Journal of neuroscience : the official journal of the Society for Neuroscience 18, 1953-62. PMID: 9482781 9. Fujita, N. et al. (1998) The Journal of neuroscience : the official journal of the Society for Neuroscience 18, 1970-8. PMID: 9482783 10. Palandri, A. et al. (2015) Cell death & disease 6, e1876. PMID: 26335717 | ||||||||
| 注意事項 | For research use only. |
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