Anti-Mouse Notch-2 Recombinant Antibody (59R1) (MC513107)

Name: Anti-Mouse Notch-2 Recombinant Antibody (59R1)
Brand: abinScience
SKU: MC513107
Price: 191 USD
Availability: InStock

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Vista general

Número de catálogo	MC513107
Reactividad de especies	Human, Mouse
Aplicaciones	ELISA, FCM
Especie huésped	Rat
Clonalidad	Monoclonal
Isotipo	IgG1, kappa
ID de clon	59R1
Objetivo	N2ICD, N2ECD, NOTCH2, hN2, Neurogenic locus notch homolog protein 2, Notch 2, Neurogenic locus notch homolog protein 3, NOTCH3, Notch 3
Nivel de endotoxinas	Please contact with the lab for this information.
Pureza	>95% as determined by SDS-PAGE.
Purificación	Protein A/G purified from cell culture supernatant.
Número de acceso	O35516, Q61982
Forma	Liquid
Buffer de almacenamiento	0.01M PBS pH 7.4 Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Fondo	Neurogenic locus notch homolog protein 2 (NOTCH2/NOTCH3) is a ~265 kDa protein. Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation. 1. Hamada, Y. et al. (1999) Development (Cambridge, England) 126, 3415-24. PMID: 10393120 2. Fukushima, H. et al. (2008) Molecular and cellular biology 28, 6402-12. PMID: 18710934
Nota	For research use only.

Imágenes

SDS-PAGE

SDS-PAGE for Anti-Mouse NOTCH2/3 Antibody (59R1)

Referencias

Datasheet

Anti-Mouse Notch-2 Recombinant Antibody (59R1).pdf

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Formula

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