Anti-Mouse NOTCH2/3 Recombinant Antibody (59R1), APC (MC513137)

Name: Anti-Mouse NOTCH2/3 Recombinant Antibody (59R1), APC
Brand: abinScience
SKU: MC513137
Price: 290 USD
Availability: InStock

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Overview

Catalog No.	MC513137
Species reactivity	Human, Mouse
Applications	ELISA, FCM
Host species	Rat
Isotype	IgG1, kappa
Clone ID	59R1
Conjugation	APC
Clonality	Monoclonal
Target	N2ICD, N2ECD, NOTCH2, hN2, Neurogenic locus notch homolog protein 2, Notch 2, Neurogenic locus notch homolog protein 3, NOTCH3, Notch 3
Endotoxin level	Please contact with the lab for this information.
Accession	O35516, Q61982
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Store at 4°C for 12 months. Protect from light. Do not freeze.
Background	Neurogenic locus notch homolog protein 2 (NOTCH2/NOTCH3) is a ~265 kDa protein. Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation. 1. Hamada, Y. et al. (1999) Development (Cambridge, England) 126, 3415-24. PMID: 10393120 2. Fukushima, H. et al. (2008) Molecular and cellular biology 28, 6402-12. PMID: 18710934
Note	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

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Anti-Mouse NOTCH2/3 Recombinant Antibody (59R1), APC.pdf

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Anti-Mouse NOTCH2/3 Recombinant Antibody (59R1), APC (MC513137)

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