Anti-Mouse Notch-2 Recombinant Antibody (59R1) (MC513107)

Name: Anti-Mouse Notch-2 Recombinant Antibody (59R1)
Brand: abinScience
SKU: MC513107
Price: 191 USD
Availability: InStock

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Обзор

Каталожный номер	MC513107
Реактивность видов	Human, Mouse
Применения	ELISA, FCM
Хозяинский вид	Rat
Клоональность	Monoclonal
Изотип	IgG1, kappa
ID клона	59R1
Цель	N2ICD, N2ECD, NOTCH2, hN2, Neurogenic locus notch homolog protein 2, Notch 2, Neurogenic locus notch homolog protein 3, NOTCH3, Notch 3
Уровень эндотоксинов	Please contact with the lab for this information.
Чистота	>95% as determined by SDS-PAGE.
Очистка	Protein A/G purified from cell culture supernatant.
Номер доступа	O35516, Q61982
Форма	Liquid
Буфер хранения	0.01M PBS pH 7.4 Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Устойчивость и хранение	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Фон	Neurogenic locus notch homolog protein 2 (NOTCH2/NOTCH3) is a ~265 kDa protein. Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation. 1. Hamada, Y. et al. (1999) Development (Cambridge, England) 126, 3415-24. PMID: 10393120 2. Fukushima, H. et al. (2008) Molecular and cellular biology 28, 6402-12. PMID: 18710934
Примечание	For research use only.

Изображения

SDS-PAGE

SDS-PAGE for Anti-Mouse NOTCH2/3 Antibody (59R1)

Ссылки

Даташит

Anti-Mouse Notch-2 Recombinant Antibody (59R1).pdf

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Formula

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