

| Número de catálogo | MX160014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Descripción |
Anti-Mouse OSTN Polyclonal Antibody (MX160014) is a rabbit polyclonal antibody detecting OSTN in ELISA, IHC, WB. Suitable for Mouse.
Highlights
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| Reactividad de especies | Mouse | ||||||||
| Aplicaciones | ELISA, IHC, WB | ||||||||
| Especie huésped | Rabbit | ||||||||
| Clonalidad | Polyclonal | ||||||||
| Isotipo | IgG | ||||||||
| Inmunógeno | E. coli - derived recombinant Mouse OSTN (Phe26-Gly130). | ||||||||
| Objetivo | OSTN, Osteocrin, Musclin | ||||||||
| Purificación | Purified by antigen affinity column. | ||||||||
| Número de acceso | P61364 | ||||||||
| Forma | Liquid | ||||||||
| Buffer de almacenamiento | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote. |
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| Información de uso del producto |
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| Estabilidad y almacenamiento | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Fondo | Osteocrin (OSTN) is a ~14 kDa protein. Hormone that acts as a ligand for natriuretic peptide receptor NPR3/NPR-C and promotes bone growth and physical endurance in muscle. Acts as a regulator of osteoblast differentiation and bone growth by binding to natriuretic peptide receptor NPR3/NPR-C, thereby preventing binding between NPR3/NPR-C and natriuretic peptides, leading to increase cGMP production. Required to enhance physical endurance: induced following physical exercise in muscle and promotes cGMP production, probably by interacting with NPR3/NPR-C. May act as an autocrine and paracrine factor linked to glucose metabolism in skeletal muscle. 1. Thomas, G. et al. (2003) The Journal of biological chemistry 278, 50563-71. PMID: 14523025 2. Moffatt, P. et al. (2007) The Journal of biological chemistry 282, 36454-62. PMID: 17951249 3. Subbotina, E. et al. (2015) Proceedings of the National Academy of Sciences of the United States of America 112, 16042-7. PMID: 26668395 4. Nishizawa, H. et al. (2004) The Journal of biological chemistry 279, 19391-5. PMID: 15044443 | ||||||||
| Nota | For research use only. |
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