

| Каталожный номер | MF951014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Описание |
Anti-Mouse PGLYRP1 Polyclonal Antibody (MF951014) is a rabbit polyclonal antibody detecting PGLYRP1 in ELISA, IHC, WB. Suitable for Mouse.
Highlights
|
||||||||
| Реактивность видов | Mouse | ||||||||
| Применения | ELISA, IHC, WB | ||||||||
| Хозяинский вид | Rabbit | ||||||||
| Клоональность | Polyclonal | ||||||||
| Изотип | IgG | ||||||||
| Иммуноген | E. coli - derived recombinant Mouse PGLYRP1 (Val41-Glu182). | ||||||||
| Цель | Peptidoglycan recognition protein 1 (Cytokine tag7) (Peptidoglycan recognition protein short) (PGRP-S) | ||||||||
| Уровень эндотоксинов | Please contact with the lab for this information. | ||||||||
| Чистота | >95% as determined by SDS-PAGE. | ||||||||
| Очистка | Purified by antigen affinity column. | ||||||||
| Номер доступа | O88593 | ||||||||
| Форма | Liquid | ||||||||
| Буфер хранения | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
||||||||
| Информация об использовании продукта |
| ||||||||
| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Фон | Peptidoglycan recognition protein 1 (PGLYRP1) is a ~20 kDa protein. Innate immunity protein that plays several important functions in antimicrobial and antitumor defense systems. Acts as a pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria and thus provides bactericidal activity. Forms an equimolar complex with heat shock protein HSPA1A and induces programmed cell death through apoptosis and necroptosis in tumor cell lines by activating the TNFR1 receptor on the target cell membrane. In addition, acts in complex with the Ca(2+)-binding protein S100A4 as a chemoattractant able to induce lymphocyte movement. Mechanistically, this complex acts as a ligand of the chemotactic receptors CCR5 and CXCR3 which are present on the cells of the immune system. 1. Dziarski, R. et al. (2003) Blood 102, 689-97. PMID: 12649138 2. Kiselev, SL. et al. (1998) The Journal of biological chemistry 273, 18633-9. PMID: 9660837 3. Kang, D. et al. (1998) Proceedings of the National Academy of Sciences of the United States of America 95, 10078-82. PMID: 9707603 4. Sashchenko, LP. et al. (2004) The Journal of biological chemistry 279, 2117-24. PMID: 14585845 | ||||||||
| Примечание | For research use only. |
Свяжитесь с нами для индивидуальных предложений, оптовых запросов и других вопросов.
Почта: [email protected]
Быстрый доступ
Свяжитесь с нами
+86-027-65523339
Building C, No. 666, Shen Dun Si Lu, Wuhan, 430206, China
中文
English
한국어
日本語
Español
Français
Русский