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| カタログ番号 | MW708013 | ||||||
|---|---|---|---|---|---|---|---|
| 種反応性 | Human, Mouse | ||||||
| アプリケーション | ELISA, IP, WB | ||||||
| 宿主種 | Rat | ||||||
| クローン性 | Monoclonal | ||||||
| アイソタイプ | IgG1, kappa | ||||||
| クローンID | SAA0274 | ||||||
| ターゲット | Signal transducer and activator of transcription 3, APRF, STAT3, Acute-phase response factor | ||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||
| 純度 | >95% as determined by SDS-PAGE. | ||||||
| 精製 | Protein A/G purified from cell culture supernatant. | ||||||
| アクセッション番号 | P42227 | ||||||
| RRID | Anti-Mouse STAT3 Antibody (SAA0274) (abinScience Cat# MW708013, RRID:AB_3725645) |
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| 形態 | Liquid | ||||||
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||||
| 背景 | Signal transducer and activator of transcription 3 (STAT3) is a ~88 kDa protein. Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Upon activation of IL6ST/gp130 signaling by interleukin-6 (IL6), binds to the IL6-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA. 1. Ren, F. et al. (2013) Cellular signalling 25, 2272-80. PMID: 23917203 2. Ren, F. et al. (2015) FEBS letters 589, 1890-6. PMID: 26026268 3. Bates, SH. et al. (2003) Nature 421, 856-9. PMID: 12594516 4. Gonzalez, RR. et al. (2006) The Journal of biological chemistry 281, 26320-8. PMID: 16825198 5. Kostromina, E. et al. (2010) Endocrinology 151, 2050-9. PMID: 20215569 6. Manukyan, I. et al. (2010) Journal of cellular and molecular medicine 14, 1707-16. PMID: 19538478 7. Choi, SM. et al. (2013) The Journal of experimental medicine 210, 551-61. PMID: 23401489 | ||||||
| 注意事項 | For research use only. |
SDS-PAGE for Anti-Mouse STAT3 Antibody (SAA0274)
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