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| カタログ番号 | MY039013 | ||||||
|---|---|---|---|---|---|---|---|
| 種反応性 | Mouse | ||||||
| アプリケーション | ELISA, IF, IHC, IP, RIA, WB | ||||||
| 宿主種 | Rat | ||||||
| クローン性 | Monoclonal | ||||||
| アイソタイプ | IgG2a, kappa | ||||||
| クローンID | PAb242 | ||||||
| ターゲット | Antigen NY-CO-13, Cellular tumor antigen p53, P53, Tumor suppressor p53, TP53, Phosphoprotein p53 | ||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||
| 純度 | >95% as determined by SDS-PAGE. | ||||||
| 精製 | Protein A/G purified from cell culture supernatant. | ||||||
| アクセッション番号 | P02340 | ||||||
| RRID | Anti-Mouse TP53/p53 Antibody (PAb242) (abinScience Cat# MY039013, RRID:AB_3725644) |
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| 形態 | Liquid | ||||||
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||||
| 背景 | Cellular tumor antigen p53 (TP53) is a ~43 kDa protein. Multifunctional transcription factor that induces cell cycle arrest, DNA repair or apoptosis upon binding to its target DNA sequence. Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Negatively regulates cell division by controlling expression of a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. 1. Allton, K. et al. (2009) Proceedings of the National Academy of Sciences of the United States of America 106, 11612-6. PMID: 19556538 2. Huarte, M. et al. (2010) Cell 142, 409-19. PMID: 20673990 3. Vaseva, AV. et al. (2012) Cell 149, 1536-48. PMID: 22726440 4. Miki, T. et al. (2013) Nature communications 4, 2444. PMID: 24051492 | ||||||
| 注意事項 | For research use only. |
Detects Recombinant Mouse TP53/p53 Protein, N-His (Cat No.: MY039012) in indirect ELISA.
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中国武漢市深敦寺路666号C棟、武漢、430206
