Anti-Mouse TREM2 Recombinant Antibody (4D9) (MV166023)

Name: Anti-Mouse TREM2 Recombinant Antibody (4D9)
Brand: abinScience
SKU: MV166023
Price: 191 USD
Availability: InStock

Fiche technique Partager le produit Copier les informations

Prix(USD) : --

Spécification :

50ug
100ug
1mg

Nombre :

Contactez-nous

Aperçu
Images
Reférences
Fiche technique
SDS

Aperçu

Numéro de catalogue	MV166023
Description	Anti-Mouse TREM2 Recombinant Antibody (4D9) (MV166023) is a mouse monoclonal antibody detecting TREM2 in ELISA, FCM, FuncS (agonist). Suitable for Mouse. Highlights ●Affinity Purified — Minimal background and high purity for reliable results. ●Multi-Application — Validated across multiple applications.
Reactivité des espèces	Mouse
Applications	ELISA, FCM, FuncS (agonist)
Espèce hôte	Mouse
Clonalité	Monoclonal
Isotype	IgG2a, kappa
ID de clone	4D9
Cible	TREM-2, Trem2, Trem2a, Trem2b, Trem2c, Triggering receptor expressed on monocytes 2, Triggering receptor expressed on myeloid cells 2
Niveau d'endotoxines	< 10 EU/mg as determined by LAL method.
Pureté	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Numéro d'accès	Q99NH8
Forme	Liquid
Tampon de stockage	0.01M PBS pH 7.4 Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Contexte	Triggering receptor expressed on myeloid cells 2 (TREM2) is a ~24 kDa protein. Forms a receptor signaling complex with TYROBP which mediates signaling and cell activation following ligand binding. Acts as a receptor for amyloid-beta protein 42, a cleavage product of the amyloid-beta precursor protein APP, and mediates its uptake and degradation by microglia. Binding to amyloid-beta 42 mediates microglial activation, proliferation, migration, apoptosis and expression of pro-inflammatory cytokines, such as IL6R and CCL3, and the anti-inflammatory cytokine ARG1. Acts as a receptor for lipoprotein particles such as LDL, VLDL, and HDL and for apolipoproteins such as APOA1, APOA2, APOB, APOE, APOE2, APOE3, APOE4, and CLU and enhances their uptake in microglia. Binds phospholipids (preferably anionic lipids) such as phosphatidylserine, phosphatidylethanolamine, phosphatidylglycerol and sphingomyelin. 1. Daws, MR. et al. (2001) European journal of immunology 31, 783-91. PMID: 11241283 2. Yeh, FL. et al. (2016) Neuron 91, 328-40. PMID: 27477018 3. Zhao, Y. et al. (2018) Neuron 97, 1023-1031.e7. PMID: 29518356 4. Zheng, H. et al. (2017) The Journal of neuroscience : the official journal of the Society for Neuroscience 37, 1772-1784. PMID: 28077724 5. Kleinberger, G. et al. (2014) Science translational medicine 6, 243ra86. PMID: 24990881 6. Takahashi, K. et al. (2005) The Journal of experimental medicine 201, 647-57. PMID: 15728241 7. Cantoni, C. et al. (2015) Acta neuropathologica 129, 429-47. PMID: 25631124 9. Filipello, F. et al. (2018) Immunity 48, 979-991.e8. PMID: 29752066
Note	For research use only.
Isotype Control	Mouse IgG2a, kappa Recombinant Isotype Control Antibody (MOPC-173) (MF533507)

Images

SDS-PAGE

SDS-PAGE for Anti-Mouse TREM2 Recombinant Antibody (4D9)

Reférences

Fiche technique

Anti-Mouse TREM2 Recombinant Antibody (4D9).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Protéines Recombinantes

Anticorps

Kits d'Essai

Anti-Mouse TREM2 Recombinant Antibody (4D9) (MV166023)

Aperçu

Images

Reférences

Fiche technique

SDS