Anti-Human/Mouse TREM2 Antibody (al002c) [al002c] (MV166013) is a mouse monoclonal antibody detecting Trem2 in Agonist, DB, EMSA, FISH, ICC, IF, IP, SPR. Suitable for Human and Mouse.
Highlights
●Multi-Application — Validated across multiple applications.
Species reactivity
Human, Mouse
Applications
Agonist, DB, EMSA, FISH, ICC, IF, IP, SPR
Host species
Mouse
Isotype
IgG1, kappa
Clone ID
al002c
Clonality
Monoclonal
Target
Triggering receptor expressed on myeloid cells 2, TREM-2, Triggering receptor expressed on monocytes 2, Trem2, Trem2a, Trem2b, Trem2c
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background
Triggering receptor expressed on myeloid cells 2 (TREM2) is a ~24 kDa protein. Forms a receptor signaling complex with TYROBP which mediates signaling and cell activation following ligand binding. Acts as a receptor for amyloid-beta protein 42, a cleavage product of the amyloid-beta precursor protein APP, and mediates its uptake and degradation by microglia. Binding to amyloid-beta 42 mediates microglial activation, proliferation, migration, apoptosis and expression of pro-inflammatory cytokines, such as IL6R and CCL3, and the anti-inflammatory cytokine ARG1. Acts as a receptor for lipoprotein particles such as LDL, VLDL, and HDL and for apolipoproteins such as APOA1, APOA2, APOB, APOE, APOE2, APOE3, APOE4, and CLU and enhances their uptake in microglia. Binds phospholipids (preferably anionic lipids) such as phosphatidylserine, phosphatidylethanolamine, phosphatidylglycerol and sphingomyelin.
1. Daws, MR. et al. (2001) European journal of immunology 31, 783-91. PMID: 11241283
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