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Anti-Mouse WDR45 Monoclonal Antibody (1A445) (MP297015)

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Anti-Mouse WDR45 Monoclonal Antibody (1A445)
Anti-Mouse WDR45 Monoclonal Antibody (1A445)
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Vista general
Número de catálogoMP297015
Descripción
Anti-Mouse WDR45 Monoclonal Antibody (1A445) [1A445] (MP297015) is a mouse monoclonal antibody detecting Wdr45 in ELISA, WB. Suitable for Mouse.
Highlights
  • ●Recombinant — Superior batch-to-batch reproducibility with defined sequences.
Reactividad de especiesMouse
AplicacionesELISA, WB
Especie huéspedMouse
ClonalidadMonoclonal
IsotipoIgG2b
ID de clon1A445
Inmunógeno Recombinant Mouse WDR45 protein.
Objetivo WD repeat domain phosphoinositide-interacting protein 4, WIPI-4, WD repeat domain X-linked 1, WD repeat-containing protein 45, Wdr45, DXImx38e, Wdrx1, Wipi4
Nivel de endotoxinas Please contact with the lab for this information.
Pureza >95% as determined by SDS-PAGE.
Purificación Protein A/G purified from cell culture supernatant.
Número de acceso Q91VM3
Forma Liquid
Buffer de almacenamiento 0.01M PBS pH 7.4.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Fondo

WD repeat domain phosphoinositide-interacting protein 4 (WDR45) is a ~39 kDa protein. Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation. Binds phosphatidylinositol 3-phosphate (PtdIns3P). Activated by the STK11/AMPK signaling pathway upon starvation, WDR45 is involved in autophagosome assembly downstream of WIPI2, regulating the size of forming autophagosomes. Together with WIPI1, promotes ATG2 (ATG2A or ATG2B)-mediated lipid transfer by enhancing ATG2-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes. Probably recruited to membranes through its PtdIns3P activity.

1. Saitsu, H. et al. (2013) Nature genetics 45, 445-9, 449e1. PMID: 23435086
2. Bakula, D. et al. (2017) Nature communications 8, 15637. PMID: 28561066
3. Maeda, S. et al. (2019) eLife 8. PMID: 31271352
Nota For research use only.
Imágenes
  • Anti-Mouse WDR45 Monoclonal Antibody (1A445)

    SDS-PAGE

    SDS-PAGE for Anti-Mouse WDR45 Monoclonal Antibody (1A445)

Referencias
Datasheet
Download SDS PDF
Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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