Anti-Mouse WDR45 Monoclonal Antibody (1A446) (MP297025)

Name: Anti-Mouse WDR45 Monoclonal Antibody (1A446)
Brand: abinScience
SKU: MP297025
Price: 194 USD
Availability: InStock

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Overview

Catalog No.	MP297025
Description	Anti-Mouse WDR45 Monoclonal Antibody (1A446) [1A446] (MP297025) is a mouse monoclonal antibody detecting Wdr45 in ELISA, WB. Suitable for Mouse. Highlights ●Recombinant — Superior batch-to-batch reproducibility with defined sequences.
Species reactivity	Mouse
Applications	ELISA, WB
Host species	Mouse
Clonality	Monoclonal
Isotype	IgG2b
Clone ID	1A446
Immunogen	Recombinant Mouse WDR45 protein.
Target	WD repeat domain phosphoinositide-interacting protein 4, WIPI-4, WD repeat domain X-linked 1, WD repeat-containing protein 45, Wdr45, DXImx38e, Wdrx1, Wipi4
Endotoxin level	Please contact with the lab for this information.
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	Q91VM3
Form	Liquid
Storage buffer	0.01M PBS pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background	WD repeat domain phosphoinositide-interacting protein 4 (WDR45) is a ~39 kDa protein. Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation. Binds phosphatidylinositol 3-phosphate (PtdIns3P). Activated by the STK11/AMPK signaling pathway upon starvation, WDR45 is involved in autophagosome assembly downstream of WIPI2, regulating the size of forming autophagosomes. Together with WIPI1, promotes ATG2 (ATG2A or ATG2B)-mediated lipid transfer by enhancing ATG2-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes. Probably recruited to membranes through its PtdIns3P activity. 1. Saitsu, H. et al. (2013) Nature genetics 45, 445-9, 449e1. PMID: 23435086 2. Bakula, D. et al. (2017) Nature communications 8, 15637. PMID: 28561066 3. Maeda, S. et al. (2019) eLife 8. PMID: 31271352
Note	For research use only.

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Datasheet

Anti-Mouse WDR45 Monoclonal Antibody (1A446).pdf

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Recombinant Proteins

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Anti-Mouse WDR45 Monoclonal Antibody (1A446) (MP297025)

Overview

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References

Datasheet

SDS