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| カタログ番号 | HS702014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-MPEG1 Polyclonal Antibody (HS702014) is a rabbit polyclonal antibody detecting MPEG1 in ELISA, IHC, WB. Suitable for Human and Pongo abelii.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human MPEG1 (Phe313-Ser580). | ||||||||
| ターゲット | Macrophage-expressed gene 1 protein, Perforin-2, Mpg-1, MPEG1, P-2, Macrophage gene 1 protein | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q2M385 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Macrophage-expressed gene 1 protein (MPEG1) is a ~78 kDa protein. Pore-forming protein involved in both innate and adaptive immunity. Plays a central role in antigen cross-presentation in dendritic cells by forming a pore in antigen-containing compartments, thereby promoting delivery of antigens for cross-presentation. Also involved in innate immune response following bacterial infection; shows antibacterial activity against a wide spectrum of Gram-positive, Gram-negative and acid-fast bacteria. Reduces the viability of the intracytosolic pathogen L.monocytogenes by inhibiting acidification of the phagocytic vacuole of host cells which restricts bacterial translocation from the vacuole to the cytosol. Required for the antibacterial activity of reactive oxygen species and nitric oxide. 1. Fields, KA. et al. (2013) Infection and immunity 81, 3045-54. PMID: 23753625 2. McCormack, RM. et al. (2015) eLife 4. PMID: 26402460 3. McCormack, RM. et al. (2017) JCI insight 2. PMID: 28422754 4. Strbo, N. et al. (2019) Experimental dermatology 28, 225-232. PMID: 30609079 5. Pang, SS. et al. (2019) Nature communications 10, 4288. PMID: 31537793 6. Merselis, LC. et al. (2020) Frontiers in immunology 11, 601584. PMID: 33224153 | ||||||||
| 注意事項 | For research use only. |
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