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| カタログ番号 | HB033014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-MSN Polyclonal Antibody (HB033014) is a rabbit polyclonal antibody detecting MSN in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Bovine, and Pig.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human MSN (Ile354-Met577). | ||||||||
| ターゲット | Membrane-organizing extension spike protein, MSN, Moesin | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P26038 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Moesin (MSN) is a ~67 kDa protein. Ezrin-radixin-moesin (ERM) family protein that connects the actin cytoskeleton to the plasma membrane and thereby regulates the structure and function of specific domains of the cell cortex. Tethers actin filaments by oscillating between a resting and an activated state providing transient interactions between moesin and the actin cytoskeleton. Once phosphorylated on its C-terminal threonine, moesin is activated leading to interaction with F-actin and cytoskeletal rearrangement. These rearrangements regulate many cellular processes, including cell shape determination, membrane transport, and signal transduction. The role of moesin is particularly important in immunity acting on both T and B-cells homeostasis and self-tolerance, regulating lymphocyte egress from lymphoid organs. 1. Huang, L. et al. (1999) The Journal of biological chemistry 274, 12803-10. PMID: 10212266 2. Urzainqui, A. et al. (2002) Immunity 17, 401-12. PMID: 12387735 3. Iontcheva, I. et al. (2004) Infection and immunity 72, 2312-20. PMID: 15039356 4. Serrador, JM. et al. (1997) The Journal of cell biology 138, 1409-23. PMID: 9298994 5. Serrador, JM. et al. (1998) Blood 91, 4632-44. PMID: 9616160 6. Lagresle-Peyrou, C. et al. (2016) The Journal of allergy and clinical immunology 138, 1681-1689.e8. PMID: 27405666 | ||||||||
| 注意事項 | For research use only. |
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