Anti-MSN Polyclonal Antibody (HB033024)

Name: Anti-MSN Polyclonal Antibody
Brand: abinScience
SKU: HB033024
Price: 168 USD
Availability: InStock

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SDS

Aperçu

Numéro de catalogue

HB033024

Description

Anti-MSN Polyclonal Antibody (HB033024) is a rabbit polyclonal antibody detecting MSN in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Reactivité des espèces

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Human MSN (Met1-Met577).

Cible

Membrane-organizing extension spike protein, MSN, Moesin

Purification

Purified by antigen affinity column.

Numéro d'accès

P26038

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

Moesin (MSN) is a ~67 kDa protein. Ezrin-radixin-moesin (ERM) family protein that connects the actin cytoskeleton to the plasma membrane and thereby regulates the structure and function of specific domains of the cell cortex. Tethers actin filaments by oscillating between a resting and an activated state providing transient interactions between moesin and the actin cytoskeleton. Once phosphorylated on its C-terminal threonine, moesin is activated leading to interaction with F-actin and cytoskeletal rearrangement. These rearrangements regulate many cellular processes, including cell shape determination, membrane transport, and signal transduction. The role of moesin is particularly important in immunity acting on both T and B-cells homeostasis and self-tolerance, regulating lymphocyte egress from lymphoid organs.

1. Huang, L. et al. (1999) The Journal of biological chemistry 274, 12803-10. PMID: 10212266

2. Urzainqui, A. et al. (2002) Immunity 17, 401-12. PMID: 12387735

3. Iontcheva, I. et al. (2004) Infection and immunity 72, 2312-20. PMID: 15039356

4. Serrador, JM. et al. (1997) The Journal of cell biology 138, 1409-23. PMID: 9298994

5. Serrador, JM. et al. (1998) Blood 91, 4632-44. PMID: 9616160

6. Lagresle-Peyrou, C. et al. (2016) The Journal of allergy and clinical immunology 138, 1681-1689.e8. PMID: 27405666

Note

For research use only.

Images

Reférences

Fiche technique

Anti-MSN Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Protéines Recombinantes

Anticorps

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