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| カタログ番号 | VK011034 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Murine minute virus/MVM NS1 Polyclonal Antibody (VK011034) is a rabbit polyclonal antibody detecting NS1 in ELISA, IHC, WB. Suitable for Murine minute virus and Parvovirus LuIII.
Highlights
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| 種反応性 | Murine minute virus (MVM) | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Murine minute virus NS1 (Tyr6-Thr253). | ||||||||
| ターゲット | NS1 | ||||||||
| 純度 | >90% | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P03134 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 別名 | Initiator protein NS1, NS1, EC:3.1.21.-, EC:3.6.4.12, NCVP1, Non-capsid protein NS-1, Non-structural protein NS1, NS1 | ||||||||
| 背景 | Initiator protein NS1 is a ~76 kDa protein. Multifunctional protein which displays endonuclease and helicase activities required for initiating and directing viral DNA replication. Also plays a role in viral packaging and transactivation of several promoters. Binds site-specifically to 2-3 approximate tandem copies of the tetranucleotide 5'TGGT3' within the origins of replication (Ori), unwinds this hairpin region and nicks one DNA strand thereby initiating the rolling circle replication (RCR). Cooperatively binds Ori with host PIF and probably other host factors, which activate the nickase function of NS1. Becomes covalently attached to the 5' end of the nick and provides a 3'OH for priming DNA synthesis. 1. Christensen, J. et al. (2002) Journal of virology 76, 6518-31. PMID: 12050365 2. Christensen, J. et al. (1995) Journal of virology 69, 5422-30. PMID: 7636987 3. Cotmore, SF. et al. (2007) Journal of virology 81, 13015-27. PMID: 17898054 4. Willwand, K. et al. (1997) The Journal of general virology 78 ( Pt 10), 2647-55. PMID: 9349487 5. Christensen, J. et al. (2001) Journal of virology 75, 7009-17. PMID: 11435581 | ||||||||
| 注意事項 | For research use only. |
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