Anti-MYL2 Polyclonal Antibody (HY376014)

Name: Anti-MYL2 Polyclonal Antibody
Brand: abinScience
SKU: HY376014
Price: 96 USD
Availability: InStock

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概要
イメージ
参考文献
データシート
SDS

概要

カタログ番号

HY376014

説明

Anti-MYL2 Polyclonal Antibody (HY376014) is a rabbit polyclonal antibody detecting MYL2 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Bovine, and Chicken.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

種反応性

Human, Mouse, Rat

アプリケーション

ELISA, IHC, WB

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

免疫原

E. coli - derived recombinant Human MYL2 (Ala2-Ile159).

ターゲット

Ventricular myosin light chain 2, Myosin light chain 2, slow skeletal/ventricular muscle isoform, Cardiac myosin light chain 2, MLC-2v, MLC-2s/v, MLC-2, Myosin regulatory light chain 2, ventricular/cardiac muscle isoform, MLC2, MYL2

精製

Purified by antigen affinity column.

アクセッション番号

P10916

形態

Liquid

保存バッファー

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。

製品使用情報

アプリケーション	希釈
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

安定性と保存

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Myosin regulatory light chain 2, ventricular/cardiac muscle isoform (MYL2) is a ~18 kDa protein. Contractile protein that plays a role in heart development and function. Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin binding sites to sustain thin filament activation as a means to fine-tune myofilament calcium sensitivity to force. During cardiogenesis plays an early role in cardiac contractility by promoting cardiac myofibril assembly.

1. Weterman, MA. et al. (2013) Brain : a journal of neurology 136, 282-93. PMID: 23365102

2. Manivannan, SN. et al. (2020) PLoS genetics 16, e1008639. PMID: 32453731

注意事項

For research use only.

イメージ

Western blot

Lane 1: Mouse heart lysate
Lane 2: Mouse skeletal muscle lysate
Lane 3: Rat heart lysate

参考文献

データシート

Anti-MYL2 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

組換えタンパク質

抗体

アッセイキット

Anti-MYL2 Polyclonal Antibody (HY376014)

概要

イメージ

参考文献

データシート

SDS