Anti-MYL2 Polyclonal Antibody (HY376014)

Name: Anti-MYL2 Polyclonal Antibody
Brand: abinScience
SKU: HY376014
Price: 96 USD
Availability: InStock

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Обзор

Каталожный номер

HY376014

Описание

Anti-MYL2 Polyclonal Antibody (HY376014) is a rabbit polyclonal antibody detecting MYL2 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Bovine, and Chicken.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Реактивность видов

Human, Mouse, Rat

Применения

ELISA, IHC, WB

Хозяинский вид

Rabbit

Клоональность

Polyclonal

Изотип

IgG

Иммуноген

E. coli - derived recombinant Human MYL2 (Ala2-Ile159).

Цель

Ventricular myosin light chain 2, Myosin light chain 2, slow skeletal/ventricular muscle isoform, Cardiac myosin light chain 2, MLC-2v, MLC-2s/v, MLC-2, Myosin regulatory light chain 2, ventricular/cardiac muscle isoform, MLC2, MYL2

Очистка

Purified by antigen affinity column.

Номер доступа

P10916

Форма

Liquid

Буфер хранения

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта

Применение	Разбавление
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Устойчивость и хранение

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Фон

Myosin regulatory light chain 2, ventricular/cardiac muscle isoform (MYL2) is a ~18 kDa protein. Contractile protein that plays a role in heart development and function. Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin binding sites to sustain thin filament activation as a means to fine-tune myofilament calcium sensitivity to force. During cardiogenesis plays an early role in cardiac contractility by promoting cardiac myofibril assembly.

1. Weterman, MA. et al. (2013) Brain : a journal of neurology 136, 282-93. PMID: 23365102

2. Manivannan, SN. et al. (2020) PLoS genetics 16, e1008639. PMID: 32453731

Примечание

For research use only.

Изображения

Western blot

Lane 1: Mouse heart lysate
Lane 2: Mouse skeletal muscle lysate
Lane 3: Rat heart lysate

Ссылки

Даташит

Anti-MYL2 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Рекомбинантные Белки

Антитела

Наборы для анализа

Anti-MYL2 Polyclonal Antibody (HY376014)

Обзор

Изображения

Ссылки

Даташит

SDS