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Anti-NNMT Polyclonal Antibody (HW468014)

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Aperçu
Numéro de catalogueHW468014
Description
Anti-NNMT Polyclonal Antibody (HW468014) is a rabbit polyclonal antibody detecting NNMT in ELISA, IHC, WB. Suitable for Human.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Reactivité des espècesHuman
ApplicationsELISA, IHC, WB
Espèce hôteRabbit
ClonalitéPolyclonal
IsotypeIgG
Immunogène E. coli - derived recombinant Human NNMT (Met1-Arg258).
Cible Nicotinamide N-methyltransferase, NNMT
Purification Purified by antigen affinity column.
Numéro d'accès P40261
Forme Liquid
Tampon de stockage 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Informations d'utilisation du produit
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stabilité et stockage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Contexte

Nicotinamide N-methyltransferase (NNMT) is a ~29 kDa protein. Catalyzes the N-methylation of nicotinamide using the universal methyl donor S-adenosyl-L-methionine to form N1-methylnicotinamide and S-adenosyl-L-homocysteine, a predominant nicotinamide/vitamin B3 clearance pathway. Plays a central role in regulating cellular methylation potential, by consuming S-adenosyl-L-methionine and limiting its availability for other methyltransferases. Actively mediates genome-wide epigenetic and transcriptional changes through hypomethylation of repressive chromatin marks, such as H3K27me3. In a developmental context, contributes to low levels of the repressive histone marks that characterize pluripotent embryonic stem cell pre-implantation state. Acts as a metabolic regulator primarily on white adipose tissue energy expenditure as well as hepatic gluconeogenesis and cholesterol biosynthesis.

1. Peng, Y. et al. (2011) Biochemistry 50, 7800-8. PMID: 21823666
2. Ulanovskaya, OA. et al. (2013) Nature chemical biology 9, 300-6. PMID: 23455543
3. Aksoy, S. et al. (1994) The Journal of biological chemistry 269, 14835-40. PMID: 8182091
4. Sperber, H. et al. (2015) Nature cell biology 17, 1523-35. PMID: 26571212
5. Eckert, MA. et al. (2019) Nature 569, 723-728. PMID: 31043742
6. Nemmara, VV. et al. (2018) ACS chemical biology 13, 2663-2672. PMID: 30044909
Note For research use only.
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
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Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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Anti-NNMT Polyclonal Antibody

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