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| カタログ番号 | HW468014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-NNMT Polyclonal Antibody (HW468014) is a rabbit polyclonal antibody detecting NNMT in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human NNMT (Met1-Arg258). | ||||||||
| ターゲット | Nicotinamide N-methyltransferase, NNMT | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P40261 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Nicotinamide N-methyltransferase (NNMT) is a ~29 kDa protein. Catalyzes the N-methylation of nicotinamide using the universal methyl donor S-adenosyl-L-methionine to form N1-methylnicotinamide and S-adenosyl-L-homocysteine, a predominant nicotinamide/vitamin B3 clearance pathway. Plays a central role in regulating cellular methylation potential, by consuming S-adenosyl-L-methionine and limiting its availability for other methyltransferases. Actively mediates genome-wide epigenetic and transcriptional changes through hypomethylation of repressive chromatin marks, such as H3K27me3. In a developmental context, contributes to low levels of the repressive histone marks that characterize pluripotent embryonic stem cell pre-implantation state. Acts as a metabolic regulator primarily on white adipose tissue energy expenditure as well as hepatic gluconeogenesis and cholesterol biosynthesis. 1. Peng, Y. et al. (2011) Biochemistry 50, 7800-8. PMID: 21823666 2. Ulanovskaya, OA. et al. (2013) Nature chemical biology 9, 300-6. PMID: 23455543 3. Aksoy, S. et al. (1994) The Journal of biological chemistry 269, 14835-40. PMID: 8182091 4. Sperber, H. et al. (2015) Nature cell biology 17, 1523-35. PMID: 26571212 5. Eckert, MA. et al. (2019) Nature 569, 723-728. PMID: 31043742 6. Nemmara, VV. et al. (2018) ACS chemical biology 13, 2663-2672. PMID: 30044909 | ||||||||
| 注意事項 | For research use only. |
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