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Anti-Human NPC1 Polyclonal Antibody (HT011014)

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Aperçu
Numéro de catalogueHT011014
Description
Anti-NPC1 Polyclonal Antibody (HT011014) is a rabbit polyclonal antibody detecting NPC1 in ELISA, IHC, WB. Suitable for Human.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Reactivité des espècesHuman
ApplicationsELISA, IHC, WB
Espèce hôteRabbit
ClonalitéPolyclonal
IsotypeIgG
Immunogène E. coli - derived recombinant Human NPC1 (Gln23-Asp266).
Cible NPC intracellular cholesterol transporter 1, Niemann-Pick C1 protein, NPC1
Purification Purified by antigen affinity column.
Numéro d'accès O15118
Forme Liquid
Tampon de stockage 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Informations d'utilisation du produit
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stabilité et stockage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Contexte

NPC intracellular cholesterol transporter 1 (NPC1) is a ~142 kDa protein. Intracellular cholesterol transporter which acts in concert with NPC2 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. Cholesterol binds to NPC1 with the hydroxyl group buried in the binding pocket. Binds oxysterol with higher affinity than cholesterol. May play a role in vesicular trafficking in glia, a process that may be crucial for maintaining the structural and functional integrity of nerve terminals (Probable).

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2. Blom, TS. et al. (2003) Human molecular genetics 12, 257-72. PMID: 12554680
3. Infante, RE. et al. (2008) Proceedings of the National Academy of Sciences of the United States of America 105, 15287-92. PMID: 18772377
4. Gong, X. et al. (2016) Cell 165, 1467-1478. PMID: 27238017
5. Carstea, ED. et al. (1997) Science (New York, N.Y.) 277, 228-31. PMID: 9211849
6. Watari, H. et al. (1999) Proceedings of the National Academy of Sciences of the United States of America 96, 805-10. PMID: 9927649
7. Kwon, HJ. et al. (2009) Cell 137, 1213-24. PMID: 19563754
8. Ebrahimi-Fakhari, D. et al. (2016) Human molecular genetics 25, 3588-3599. PMID: 27378690
Note For research use only.
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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Anti-Human NPC1 Polyclonal Antibody

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