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| カタログ番号 | HW549014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-p21/CDKN1A Polyclonal Antibody (HW549014) is a rabbit polyclonal antibody detecting CDKN1A in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human CDKN1A (Met1-Pro164). | ||||||||
| ターゲット | CDKN1, MDA-6, Cyclin-dependent kinase inhibitor 1, CIP1, WAF1, CDKN1A, p21, PIC1, Melanoma differentiation-associated protein 6, MDA6, SDI1, CDK-interacting protein 1, CAP20 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P38936 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Cyclin-dependent kinase inhibitor 1 (p21/CDKN1A) is a ~18 kDa protein. Plays an important role in controlling cell cycle progression and DNA damage-induced G2 arrest. Involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage. Also involved in p53-independent DNA damage-induced G2 arrest mediated by CREB3L1 in astrocytes and osteoblasts. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. 1. LaBaer, J. et al. (1997) Genes & development 11, 847-62. PMID: 9106657 2. Ducoux, M. et al. (2001) The Journal of biological chemistry 276, 49258-66. PMID: 11595739 | ||||||||
| 注意事項 | For research use only. |
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