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| カタログ番号 | HV629014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-PARK7 Polyclonal Antibody (HV629014) is a rabbit polyclonal antibody detecting PARK7 in ELISA, IHC, WB. Suitable for Human, Bovine, Chicken, Mouse, and Rat.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human PARK7 (Met1-Asp189). | ||||||||
| ターゲット | Parkinson disease protein 7, Oncogene DJ1, Parkinsonism-associated deglycase, DJ-1, PARK7, Maillard deglycase, Protein/nucleic acid deglycase DJ-1, Protein DJ-1 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q99497 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Parkinson disease protein 7 (PARK7) is a ~19 kDa protein. Multifunctional protein with controversial molecular function which plays an important role in cell protection against oxidative stress and cell death acting as oxidative stress sensor and redox-sensitive chaperone and protease. It is involved in neuroprotective mechanisms like the stabilization of NFE2L2 and PINK1 proteins, male fertility as a positive regulator of androgen signaling pathway as well as cell growth and transformation through, for instance, the modulation of NF-kappa-B signaling pathway. Has been described as a protein and nucleotide deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins or nucleotides and reactive carbonyl groups of glyoxals. But this function is rebuted by other works. As a protein deglycase, repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and lactate or glycolate, respectively. 1. Honbou, K. et al. (2003) The Journal of biological chemistry 278, 31380-4. PMID: 12796482 2. Clements, CM. et al. (2006) Proceedings of the National Academy of Sciences of the United States of America 103, 15091-6. PMID: 17015834 3. Junn, E. et al. (2009) Journal of neuroscience research 87, 123-9. PMID: 18711745 4. Xiong, H. et al. (2009) The Journal of clinical investigation 119, 650-60. PMID: 19229105 5. Chen, J. et al. (2010) Human molecular genetics 19, 2395-408. PMID: 20304780 6. Richarme, G. et al. (2015) The Journal of biological chemistry 290, 1885-97. PMID: 25416785 7. Advedissian, T. et al. (2016) Biochemical and biophysical research communications 473, 87-91. PMID: 26995087 8. Matsuda, N. et al. (2017) Scientific reports 7, 12816. PMID: 28993701 9. Niki, T. et al. (2003) Molecular cancer research : MCR 1, 247-61. PMID: 12612053 10. Taira, T. et al. (2004) EMBO reports 5, 213-8. PMID: 14749723 | ||||||||
| 注意事項 | For research use only. |
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