Anti-PIP4K2B/PIP4KII-beta Polyclonal Antibody (HX081014)

Name: Anti-PIP4K2B/PIP4KII-beta Polyclonal Antibody
Brand: abinScience
SKU: HX081014
Price: 168 USD
Availability: InStock

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SDS

Обзор

Каталожный номер

HX081014

Описание

Anti-PIP4K2B/PIP4KII-beta Polyclonal Antibody (HX081014) is a rabbit polyclonal antibody detecting PIP4KII-beta in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Реактивность видов

Human, Mouse, Rat

Применения

ELISA, IHC, WB

Хозяинский вид

Rabbit

Клоональность

Polyclonal

Изотип

IgG

Иммуноген

E. coli - derived recombinant Human PIP4K2B/PIP4KII-beta (Ser2-Thr416).

Цель

1-phosphatidylinositol 5-phosphate 4-kinase 2-beta, Phosphatidylinositol 5-phosphate 4-kinase type-2 beta, PtdIns(5)P-4-kinase isoform 2-beta, Phosphatidylinositol 5-phosphate 4-kinase type II beta, PIP4KII-beta, Diphosphoinositide kinase 2-beta, PI(5)P 4-kinase type II beta, PIP5K2B, PIP4K2B

Очистка

Purified by antigen affinity column.

Номер доступа

P78356

Форма

Liquid

Буфер хранения

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта

Применение	Разбавление
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Устойчивость и хранение

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Фон

Phosphatidylinositol 5-phosphate 4-kinase type-2 beta (PIP4K2B/PIP4KII-beta) is a ~47 kDa protein. Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. Preferentially utilizes GTP, rather than ATP, for PI(5)P phosphorylation and its activity reflects changes in direct proportion to the physiological GTP concentration. Its GTP-sensing activity is critical for metabolic adaptation. PIP4Ks negatively regulate insulin signaling through a catalytic-independent mechanism. They interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3.

1. Sumita, K. et al. (2016) Molecular cell 61, 187-98. PMID: 26774281

2. Castellino, AM. et al. (1997) The Journal of biological chemistry 272, 5861-70. PMID: 9038203

3. Wang, DG. et al. (2019) Cell reports 27, 1991-2001.e5. PMID: 31091439

Примечание

For research use only.

Изображения

Ссылки

Даташит

Anti-PIP4K2B/PIP4KII-beta Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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