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| カタログ番号 | HB853014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-PTN Polyclonal Antibody (HB853014) is a rabbit polyclonal antibody detecting PTN in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Bovine, and Chicken.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human PTN (Gly33-Asp168). | ||||||||
| ターゲット | Heparin-binding neurite outgrowth-promoting factor 1, Heparin-binding brain mitogen, PTN, HBGF-8, Pleiotrophin, Heparin-binding growth factor 8, HBBM, HBNF-1, NEGF1, Osteoblast-specific factor 1, HBNF, HBNF1, Heparin-binding growth-associated molecule, HB-GAM, OSF-1, Heparin-binding neurite outgrowth-promoting factor | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P21246 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Pleiotrophin (PTN) is a ~18 kDa protein. Secreted growth factor that mediates its signal through cell-surface proteoglycan and non-proteoglycan receptors. Binds cell-surface proteoglycan receptor via their chondroitin sulfate (CS) groups. Thereby regulates many processes like cell proliferation, cell survival, cell growth, cell differentiation and cell migration in several tissues namely neuron and bone. Also plays a role in synaptic plasticity and learning-related behavior by inhibiting long-term synaptic potentiation. Binds PTPRZ1, leading to neutralization of the negative charges of the CS chains of PTPRZ1, inducing PTPRZ1 clustering, thereby causing the dimerization and inactivation of its phosphatase activity leading to increased tyrosine phosphorylation of each of the PTPRZ1 substrates like ALK, CTNNB1 or AFAP1L2 in order to activate the PI3K-AKT pathway. 1. Stoica, GE. et al. (2001) The Journal of biological chemistry 276, 16772-9. PMID: 11278720 2. Fukada, M. et al. (2006) FEBS letters 580, 4051-6. PMID: 16814777 3. Mikelis, C. et al. (2009) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 23, 1459-69. PMID: 19141530 4. Ryan, E. et al. (2016) The FEBS journal 283, 1488-503. PMID: 26896299 5. Kuboyama, K. et al. (2016) The Journal of biological chemistry 291, 18117-28. PMID: 27445335 6. Wellstein, A. et al. (1992) The Journal of biological chemistry 267, 2582-7. PMID: 1733956 7. Kretschmer, PJ. et al. (1991) Growth factors (Chur, Switzerland) 5, 99-114. PMID: 1768439 8. Imai, S. et al. (2009) Bone 44, 785-94. PMID: 19442624 | ||||||||
| 注意事項 | For research use only. |
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