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| カタログ番号 | HV750014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human PXDN (Gln1285-Ala1475). | ||||||||
| ターゲット | Peroxidasin homolog, VPO1, MG50, p53-responsive gene 2 protein, Vascular peroxidase 1, KIAA0230, Melanoma-associated antigen MG50, VPO, PXDN, PRG2 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q92626 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Peroxidasin homolog (PXDN) is a ~165 kDa protein. Catalyzes the two-electron oxidation of bromide by hydrogen peroxide and generates hypobromite as a reactive intermediate which mediates the formation of sulfilimine cross-links between methionine and hydroxylysine residues within an uncross-linked collagen IV/COL4A1 NC1 hexamer. In turns, directly contributes to the collagen IV network-dependent fibronectin/FN and laminin assembly, which is required for full extracellular matrix (ECM)-mediated signaling. Thus, sulfilimine cross-links are essential for growth factor-induced cell proliferation and survival in endothelial cells, an event essential to basement membrane integrity. In addition, through the bromide oxidation, may promote tubulogenesis and induce angiogenesis through ERK1/2, Akt, and FAK pathways. Moreover brominates alpha2 collagen IV chain/COL4A2 at 'Tyr-1485' and leads to bromine enrichment of the basement membranes. 1. Cheng, G. et al. (2008) Free radical biology & medicine 45, 1682-94. PMID: 18929642 2. Péterfi, Z. et al. (2009) The American journal of pathology 175, 725-35. PMID: 19590037 3. Bhave, G. et al. (2012) Nature chemical biology 8, 784-90. PMID: 22842973 4. Lázár, E. et al. (2015) Free radical biology & medicine 83, 273-82. PMID: 25708780 5. Soudi, M. et al. (2015) The Journal of biological chemistry 290, 10876-90. PMID: 25713063 6. Colon, S. et al. (2016) The Journal of biological chemistry 291, 24009-24016. PMID: 27697841 7. Paumann-Page, M. et al. (2017) The Journal of biological chemistry 292, 4583-4592. PMID: 28154175 8. Kovács, HA. et al. (2021) Antioxidants (Basel, Switzerland) 10. PMID: 34679700 9. Lee, SW. et al. (2020) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 34, 10228-10241. PMID: 32543734 10. He, C. et al. (2020) Proceedings of the National Academy of Sciences of the United States of America 117, 15827-15836. PMID: 32571911 | ||||||||
| 注意事項 | For research use only. |
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