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| カタログ番号 | HB244014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-RAB5A Polyclonal Antibody (HB244014) is a rabbit polyclonal antibody detecting RAB5A in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Bovine, and Dog.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human RAB5A (Asp136-Asn215). | ||||||||
| ターゲット | Ras-related protein Rab-5A, RAB5A, RAB5 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P20339 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Ras-related protein Rab-5A (RAB5A) is a ~23 kDa protein. The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes and involved in early endocytic trafficking. Required for EEA1 recruitment to early endosomes. Recruits FERRY complex to early endosomes, where FERRY links early endosomes with a subgroup of mRNAs to enable mRNA intracellular distribution. 1. Hoffenberg, S. et al. (2000) The Journal of biological chemistry 275, 24661-9. PMID: 10818110 2. Fouraux, MA. et al. (2004) Molecular biology of the cell 15, 611-24. PMID: 14617813 3. Zhu, G. et al. (2004) Nature structural & molecular biology 11, 975-83. PMID: 15378032 4. Haas, AK. et al. (2005) Nature cell biology 7, 887-93. PMID: 16086013 5. Hunker, CM. et al. (2006) Biochemical and biophysical research communications 340, 967-75. PMID: 16410077 6. Fuchs, E. et al. (2007) The Journal of cell biology 177, 1133-43. PMID: 17562788 7. Quentin, D. et al. (2023) Molecular cell 83, 1856-1871.e9. PMID: 37267906 8. Gauthier-Campbell, C. et al. (2004) Molecular biology of the cell 15, 2205-17. PMID: 14978216 9. Baietti, MF. et al. (2012) Nature cell biology 14, 677-85. PMID: 22660413 | ||||||||
| 注意事項 | For research use only. |
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