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| カタログ番号 | RW302014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Rat SCNN1A/SCNN1 Polyclonal Antibody (RW302014) is a rabbit polyclonal antibody detecting Scnn1a in ELISA, IHC, WB. Suitable for Human, Mouse, Pan troglodytes, and Rat.
Highlights
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| 種反応性 | Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Rat SCNN1A/SCNN1 (Glu132-Asp391). | ||||||||
| ターゲット | Amiloride-sensitive sodium channel subunit alpha, Alpha-NaCH, Epithelial Na(+) channel subunit alpha, Alpha-ENaC, Nonvoltage-gated sodium channel 1 subunit alpha, SCNEA, Scnn1a, Renac | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P37089 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Epithelial sodium channel subunit alpha (SCNN1A/SCNN1) is a ~78 kDa protein. This is one of the three pore-forming subunits of the heterotrimeric epithelial sodium channel (ENaC), a critical regulator of sodium balance and fluid homeostasis. ENaC operates in epithelial tissues, where it mediates the electrodiffusion of sodium ions from extracellular fluid through the apical membrane of cells, with water following osmotically. It plays a key role in maintaining sodium homeostasis through electrogenic sodium reabsorption in the kidneys. Additionally, ENaC is essential for airway surface liquid homeostasis, which is crucial for proper mucus clearance. 1. Lingueglia, E. et al. (1994) The Journal of biological chemistry 269, 13736-9. PMID: 8188647 2. Gründer, S. et al. (1997) The EMBO journal 16, 899-907. PMID: 9118951 3. Lingueglia, E. et al. (1993) FEBS letters 318, 95-9. PMID: 8382172 | ||||||||
| 注意事項 | For research use only. |
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