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| カタログ番号 | HC453024 | ||||||
|---|---|---|---|---|---|---|---|
| 説明 |
Anti-RELA Polyclonal Antibody (HC453024) is a rabbit polyclonal antibody detecting RELA in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||
| アプリケーション | ELISA, IHC, WB | ||||||
| 宿主種 | Rabbit | ||||||
| クローン性 | Polyclonal | ||||||
| アイソタイプ | IgG | ||||||
| 免疫原 | E. coli - derived recombinant Human RELA (Gly18-Asp291). | ||||||
| ターゲット | NFKB3, Nuclear factor NF-kappa-B p65 subunit, Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, RELA, Transcription factor p65 | ||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||
| 精製 | Purified by antigen affinity column. | ||||||
| アクセッション番号 | Q04206 | ||||||
| 形態 | Liquid | ||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. | ||||||
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. | ||||||
| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||
| 背景 | Transcription factor p65 (RELA/NFkB p65) is a ~60 kDa protein. NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The heterodimeric RELA-NFKB1 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. 1. Bettelli, E. et al. (2005) Proceedings of the National Academy of Sciences of the United States of America 102, 5138-43. PMID: 15790681 2. Yin, X. et al. (2021) Cell reports 34, 108628. PMID: 33440148 | ||||||
| 注意事項 | For research use only. |
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