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Anti-Reovirus Outer capsid protein sigma-1 Polyclonal Antibody (VK138014)

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Vista general
Número de catálogoVK138014
Descripción
Anti-Reovirus Outer capsid protein sigma-1 Polyclonal Antibody (VK138014) is a rabbit polyclonal antibody detecting Outer capsid protein sigma-1. Suitable for Reovirus type 1.
Reactividad de especiesMammalian orthoreovirus 1 (MRV1)
AplicacionesELISA, IHC, WB
Especie huéspedRabbit
ClonalidadPolyclonal
IsotipoIgG
Inmunógeno E. coli - derived recombinant Reovirus Outer capsid protein sigma-1 (Val258-Arg470).
Objetivo Cell attachment protein, Hemagglutinin, Outer capsid protein sigma-1, S1, Sigma1
Nivel de endotoxinas Please contact with the lab for this information.
Purificación Purified by antigen affinity column.
Número de acceso P04506
Forma Liquid
Buffer de almacenamiento 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto
Aplicación Dilución
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Fondo

Outer capsid protein sigma-1 is a ~51 kDa protein. Fiber-like molecule that attaches the virion to the host cell membrane by binding with initial low affinity to sialic acid containing proteins, followed by high-affinity bindingto the entry receptor F11R/JAM-A. Also binds to the ganglioside GM2 as an alternate receptor, this binding is serotype-specific. The interaction of sigma-1 with F11R is required for NF-kB activation and apoptosis. Binding to both sialic acid and F11R is required to induce maximal levels of apoptosis.

1. Reiss, K. et al. (2012) PLoS pathogens 8, e1003078. PMID: 23236285
Nota For research use only
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Formula
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Stock Solution
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