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| カタログ番号 | VK676024 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Rotavirus A Outer capsid protein VP4 Polyclonal Antibody (VK676024) is a rabbit polyclonal antibody detecting Outer capsid protein VP4 in ELISA, IHC, WB. Suitable for Rotavirus A.
Highlights
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| 種反応性 | Rotavirus A (RV-A) | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Rotavirus A Outer capsid protein VP4 (Ala248-Tyr480). | ||||||||
| ターゲット | Outer capsid protein VP4, Hemagglutinin, Outer capsid protein VP8*, Outer capsid protein VP5* | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P12976 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Outer capsid protein VP4 is a ~86 kDa protein. Spike-forming protein that mediates virion attachment to the host epithelial cell receptors and plays a major role in cell penetration, determination of host range restriction and virulence. Rotavirus attachment and entry into the host cell probably involves multiple sequential contacts between the outer capsid proteins VP4 and VP7, and the cell receptors. It is subsequently lost, together with VP7, following virus entry into the host cell. Following entry into the host cell, low intracellular or intravesicular Ca(2+) concentration probably causes the calcium-stabilized VP7 trimers to dissociate from the virion. This step is probably necessary for the membrane-disrupting entry step and the release of VP4, which is locked onto the virion by VP7. | ||||||||
| 注意事項 | For research use only |
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