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| カタログ番号 | VK577014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-SARS-CoV-2 ORF3a Polyclonal Antibody (VK577014) is a rabbit polyclonal antibody detecting ORF3a protein in ELISA, IHC, WB.
Highlights
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| 種反応性 | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant SARS-CoV-2 ORF3a (Leu115-Leu275). | ||||||||
| ターゲット | ORF3a protein, ORF3a, Accessory protein 3a, Protein 3a, Protein U274, Protein X1, 3a | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P0DTC3 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | ORF3a protein is a ~31 kDa protein. Plays a role in viral egress via lysosomal trafficking. Forms homotetrameric ion channels (viroporins) localized at endosomes and lysosomes, that may induce deacidification of lysosomes, allowing safe egress of virions via lysosomal trafficking. Also blocks autolysosome formation by binding and sequestering the host component VPS39 for homotypic fusion and protein sorting (HOPS) on late endosomes. This prevents fusion of autophagosomes with lysosomes, disrupting autophagy and facilitating virus egress. Induces host RETREG1/FAM134B-dependent reticulophagy by interacting with host HMGB1 and enhancing the association between HMGB1 and host BECN1. 1. Ghosh, S. et al. (2020) Cell 183, 1520-1535.e14. PMID: 33157038 2. Miao, G. et al. (2021) Developmental cell 56, 427-442.e5. PMID: 33422265 3. Kern, DM. et al. (2021) Nature structural & molecular biology 28, 573-582. PMID: 34158638 4. Zhang, X. et al. (2022) Autophagy 18, 2576-2592. PMID: 35239449 | ||||||||
| 注意事項 | For research use only. |
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