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Anti-SFN Polyclonal Antibody (HB182014)

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Aperçu
Numéro de catalogueHB182014
Description
Anti-SFN Polyclonal Antibody (HB182014) is a rabbit polyclonal antibody detecting SFN in ELISA, IHC, WB. Suitable for Human, Mouse.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
  • ●Multi-Species — Cross-reactive for translational research.
Reactivité des espècesHuman, Mouse
ApplicationsELISA, IHC, WB
Espèce hôteRabbit
ClonalitéPolyclonal
IsotypeIgG
Immunogène E. coli - derived recombinant Human SFN (Met1-Ser248).
Cible Stratifin, Epithelial cell marker protein 1, HME1, 14-3-3 protein sigma, SFN
Purification Purified by antigen affinity column.
Numéro d'accès P31947
Forme Liquid
Tampon de stockage 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Informations d'utilisation du produit
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stabilité et stockage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Contexte

14-3-3 protein sigma (SFN) is a ~27 kDa protein. Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Promotes cytosolic retention of GBP1 GTPase by binding to phosphorylated GBP1, thereby inhibiting the innate immune response. Also acts as a TP53/p53-regulated inhibitor of G2/M progression.

1. Wilker, EW. et al. (2005) The Journal of biological chemistry 280, 18891-8. PMID: 15731107
2. Rose, R. et al. (2012) Journal of structural biology 180, 65-72. PMID: 22634725
3. Stevers, LM. et al. (2017) The Biochemical journal 474, 1273-1287. PMID: 28202711
4. Fisch, D. et al. (2023) Science (New York, N.Y.) 382, eadg2253. PMID: 37797010
7. Rietscher, K. et al. (2018) Journal of cell science 131. PMID: 29678907
Note For research use only.
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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Anti-SFN Polyclonal Antibody

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