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| カタログ番号 | HB182014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-SFN Polyclonal Antibody (HB182014) is a rabbit polyclonal antibody detecting SFN in ELISA, IHC, WB. Suitable for Human, Mouse.
Highlights
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| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human SFN (Met1-Ser248). | ||||||||
| ターゲット | Stratifin, Epithelial cell marker protein 1, HME1, 14-3-3 protein sigma, SFN | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P31947 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | 14-3-3 protein sigma (SFN) is a ~27 kDa protein. Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Promotes cytosolic retention of GBP1 GTPase by binding to phosphorylated GBP1, thereby inhibiting the innate immune response. Also acts as a TP53/p53-regulated inhibitor of G2/M progression. 1. Wilker, EW. et al. (2005) The Journal of biological chemistry 280, 18891-8. PMID: 15731107 2. Rose, R. et al. (2012) Journal of structural biology 180, 65-72. PMID: 22634725 3. Stevers, LM. et al. (2017) The Biochemical journal 474, 1273-1287. PMID: 28202711 4. Fisch, D. et al. (2023) Science (New York, N.Y.) 382, eadg2253. PMID: 37797010 7. Rietscher, K. et al. (2018) Journal of cell science 131. PMID: 29678907 | ||||||||
| 注意事項 | For research use only. |
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