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| カタログ番号 | HV634014 | ||||||||
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| 説明 |
Anti-SIRT4 Polyclonal Antibody (HV634014) is a rabbit polyclonal antibody detecting SIRT4 in ELISA, IHC, WB. Suitable for Human, Mouse, and Bovine.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human SIRT4 (Ser28-Cys314). | ||||||||
| ターゲット | NAD-dependent protein lipoamidase sirtuin-4, mitochondrial, SIR2-like protein 4, SIR2L4, NAD-dependent protein deacetylase sirtuin-4, NAD-dependent ADP-ribosyltransferase sirtuin-4, SIRT4, Regulatory protein SIR2 homolog 4 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q9Y6E7 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | NAD-dependent protein lipoamidase sirtuin-4, mitochondrial (SIRT4) is a ~35 kDa protein. Acts as a NAD-dependent protein lipoamidase, biotinylase, deacetylase and ADP-ribosyl transferase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP-ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitochondrial glutamine metabolism by mediating mono ADP-ribosylation of GLUD1: expressed in response to DNA damage and negatively regulates anaplerosis by inhibiting GLUD1, leading to block metabolism of glutamine into tricarboxylic acid cycle and promoting cell cycle arrest. 1. Haigis, MC. et al. (2006) Cell 126, 941-54. PMID: 16959573 2. Ahuja, N. et al. (2007) The Journal of biological chemistry 282, 33583-33592. PMID: 17715127 3. Feldman, JL. et al. (2013) The Journal of biological chemistry 288, 31350-6. PMID: 24052263 4. Mathias, RA. et al. (2014) Cell 159, 1615-25. PMID: 25525879 | ||||||||
| 注意事項 | For research use only. |
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