Anti-Human alpha-Synuclein Polyclonal Antibody (HW755014)

Name: Anti-Human alpha-Synuclein Polyclonal Antibody
Brand: abinScience
SKU: HW755014
Price: 168 USD
Availability: InStock

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Aperçu

Numéro de catalogue

HW755014

Description

Anti-SNCA Polyclonal Antibody (HW755014) is a rabbit polyclonal antibody detecting SNCA in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Ateles geoffroyi, and Bovine.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Reactivité des espèces

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Human SNCA (Met1-Ala140).

Cible

Alpha-synuclein, PARK1, Non-A4 component of amyloid precursor, NACP, Non-A beta component of AD amyloid, SNCA

Purification

Purified by antigen affinity column.

Numéro d'accès

P37840

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

Alpha-synuclein (SNCA) is a ~14 kDa protein. Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Also acts as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. This chaperone activity is important to sustain normal SNARE-complex assembly during aging.

1. Burré, J. et al. (2010) Science (New York, N.Y.) 329, 1663-7. PMID: 20798282

2. Butler, B. et al. (2015) The Journal of biological chemistry 290, 29542-54. PMID: 26442590

3. Logan, T. et al. (2017) Nature neuroscience 20, 681-689. PMID: 28288128

4. Huang, CC. et al. (2018) Journal of cell science 131. PMID: 30404828

Note

For research use only.

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