Anti-STIM1 Polyclonal Antibody (HC687014)

Name: Anti-STIM1 Polyclonal Antibody
Brand: abinScience
SKU: HC687014
Price: 168 USD
Availability: InStock

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Reférences
Fiche technique
SDS

Aperçu

Numéro de catalogue

HC687014

Reactivité des espèces

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Human STIM1 (Ser28-Leu211).

Cible

STIM1, Stromal interaction molecule 1, GOK

Purification

Purified by antigen affinity column.

Numéro d'accès

Q13586

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

Stromal interaction molecule 1 (STIM1) is a ~77 kDa protein. Acts as a Ca(2+) sensor that gates two major inward rectifying Ca(2+) channels at the plasma membrane: Ca(2+) release-activated Ca(2+) (CRAC) channels and arachidonate-regulated Ca(2+)-selective (ARC) channels. Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates CRAC channel pore-forming subunits ORA1, ORA2 and ORAI3 to generate sustained and oscillatory Ca(2+) entry. Involved in enamel formation.

1. Roos, J. et al. (2005) The Journal of cell biology 169, 435-45. PMID: 15866891

2. Liou, J. et al. (2005) Current biology : CB 15, 1235-41. PMID: 16005298

3. Zhang, SL. et al. (2005) Nature 437, 902-5. PMID: 16208375

4. Spassova, MA. et al. (2006) Proceedings of the National Academy of Sciences of the United States of America 103, 4040-5. PMID: 16537481

5. Peinelt, C. et al. (2006) Nature cell biology 8, 771-3. PMID: 16733527

6. Soboloff, J. et al. (2006) The Journal of biological chemistry 281, 20661-20665. PMID: 16766533

7. Mercer, JC. et al. (2006) The Journal of biological chemistry 281, 24979-90. PMID: 16807233

8. Stathopulos, PB. et al. (2008) Cell 135, 110-22. PMID: 18854159

9. Yuan, JP. et al. (2009) Nature cell biology 11, 337-43. PMID: 19182790

10. Park, CY. et al. (2009) Cell 136, 876-90. PMID: 19249086

Note

For research use only.

Images

Reférences

Fiche technique

Anti-STIM1 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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