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| カタログ番号 | JN886014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| ブランド | abinScience | ||||||||
| 説明 |
Anti-Streptococcus pyogenes speB/Streptopain Polyclonal Antibody (JN886014) is a rabbit polyclonal antibody detecting Streptopain in ELISA, IHC, WB.
Highlights
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| 種反応性 | Streptococcus pyogenes | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Streptococcus pyogenes speB/Streptopain (Gln146-Pro398). | ||||||||
| ターゲット | Streptopain, 3.4.22.10, Exotoxin type B, SPE B, Streptococcal cysteine proteinase, Streptococcus peptidase A, SPP, speB | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P0C0J0 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Streptopain (speB) is a ~43 kDa protein. Cysteine protease that acts as a key streptococcal virulence factor by cleaving host proteins involved in immune response. Triggers inflammation by mediating cleavage of host proteins, which can both promote host pathogenesis by triggering sterile inflammation and/or restrict streptococcal infection, depending on host immune statue and infection site. Cleaves host gasdermin-A (GSDMA) in epithelial cells, promoting GSDMA activation and formation of gasdermin pores, triggering pyroptosis. Pyroptosis triggers the elimination of the infected skin cell, depriving the pathogen of its protective niche, while inducing an inflammatory response. This ultimately prevents bacterial penetration of the epithelial barrier and a subsequent systemic dissemination of the pathogen. 1. Doran, JD. et al. (1999) European journal of biochemistry 263, 145-51. PMID: 10429198 2. Nomizu, M. et al. (2001) The Journal of biological chemistry 276, 44551-6. PMID: 11553627 3. Yu, CE. et al. (1991) Infection and immunity 59, 211-5. PMID: 1987034 4. González-Páez, GE. et al. (2012) The Journal of biological chemistry 287, 24412-26. PMID: 22645124 5. Musser, JM. et al. (1996) Infection and immunity 64, 1913-7. PMID: 8675287 6. Lukomski, S. et al. (1997) The Journal of clinical investigation 99, 2574-80. PMID: 9169486 7. Kuo, CF. et al. (1999) Infection and immunity 67, 126-30. PMID: 9864206 8. Kapur, V. et al. (1993) Proceedings of the National Academy of Sciences of the United States of America 90, 7676-80. PMID: 7689226 9. Kapur, V. et al. (1993) Microbial pathogenesis 15, 327-46. PMID: 7516997 | ||||||||
| 注意事項 | For research use only. |
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