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| カタログ番号 | HX224014 | ||||||||
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| 説明 |
Anti-SUMO1 Polyclonal Antibody (HX224014) is a rabbit polyclonal antibody detecting SUMO1 in ELISA, IHC, WB. Suitable for Bovine, Cervus nippon, Danio rerio, Chicken, and Human.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human SUMO1 (Met1-Val101). | ||||||||
| ターゲット | SUMO-1, SMT3C, SMT3H3, Sentrin, GMP1, Ubiquitin-like protein UBL1, UBL1, Small ubiquitin-related modifier 1, Ubiquitin-homology domain protein PIC1, SUMO1, Ubiquitin-like protein SMT3C, SMT3 homolog 3, Smt3C, GAP-modifying protein 1 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P63165 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Small ubiquitin-related modifier 1 (SUMO1) is a ~11 kDa protein. Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Covalently attached to the voltage-gated potassium channel KCNB1; this modulates the gating characteristics of KCNB1. 1. Dai, XQ. et al. (2009) Journal of cell science 122, 775-9. PMID: 19223394 2. Sun, X. et al. (2014) PloS one 9, e92746. PMID: 24651376 | ||||||||
| 注意事項 | For research use only. |
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