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| カタログ番号 | VK099024 | ||||
|---|---|---|---|---|---|
| 説明 |
Anti-SV40 Large T Antigen Polyclonal Antibody (VK099024) is a rabbit polyclonal antibody detecting Large T antigen in ELISA, IHC, WB. Suitable for Simian virus 40.
Highlights
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| 種反応性 | Simian virus 40 (SV40) | ||||
| アプリケーション | ELISA, IHC, WB | ||||
| 宿主種 | Rabbit | ||||
| クローン性 | Polyclonal | ||||
| アイソタイプ | IgG | ||||
| 免疫原 | E. coli - derived recombinant SV40 Large T Antigen (Gly251-Asp627). | ||||
| ターゲット | Large T antigen, LT, LT-AG, 5.6.2.4, DNA 3'-5' helicase large T antigen | ||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||
| 純度 | >95% as determined by SDS-PAGE. | ||||
| 精製 | Purified by antigen affinity column. | ||||
| アクセッション番号 | P03070 | ||||
| 形態 | Liquid | ||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||
| 背景 | Large T antigen is a ~81 kDa protein. Isoform large T antigen is a key early protein essential for both driving viral replication and inducing cellular transformation. Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle and by autoregulating the synthesis of viral early mRNA. Displays highly oncogenic activities by corrupting the host cellular checkpoint mechanisms that guard cell division and the transcription, replication, and repair of DNA. Participates in the modulation of cellular gene expression preceeding viral DNA replication. This step involves binding to host key cell cycle regulators retinoblastoma protein RB1/pRb and TP53. 1. Goetz, GS. et al. (1988) The Journal of biological chemistry 263, 383-92. PMID: 2826443 2. Wiekowski, M. et al. (1988) The Journal of biological chemistry 263, 436-42. PMID: 2826446 | ||||
| 注意事項 | For research use only |
Lane 1: recombinant SV40 Large T Antigen (Catalog No: VK099022)
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