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| カタログ番号 | HV024014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-TLR7 Polyclonal Antibody (HV024014) is a rabbit polyclonal antibody detecting TLR7 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human TLR7 (Leu24-Ser348). | ||||||||
| ターゲット | TLR7, Toll-like receptor 7 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q9NYK1 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Toll-like receptor 7 (TLR7) is a ~120 kDa protein. Endosomal receptor that plays a key role in innate and adaptive immunity. Controls host immune response against pathogens through recognition of uridine-containing single strand RNAs (ssRNAs) of viral origin or guanosine analogs. Upon binding to agonists, undergoes dimerization that brings TIR domains from the two molecules into direct contact, leading to the recruitment of TIR-containing downstream adapter MYD88 through homotypic interaction. In turn, the Myddosome signaling complex is formed involving IRAK4, IRAK1, TRAF6, TRAF3 leading to activation of downstream transcription factors NF-kappa-B and IRF7 to induce pro-inflammatory cytokines and interferons, respectively. In plasmacytoid dendritic cells, RNASET2 endonuclease cooperates with PLD3 or PLD4 5'->3' exonucleases to process RNA and release 2',3'-cyclic guanosine monophosphate (2',3'-cGMP) and cytidine-rich RNA fragments that occupy TLR7 ligand-binding pockets and trigger a signaling-competent state. 1. Diebold, SS. et al. (2004) Science (New York, N.Y.) 303, 1529-31. PMID: 14976261 2. Heinz, LX. et al. (2020) Nature 581, 316-322. PMID: 32433612 3. Lee, J. et al. (2003) Proceedings of the National Academy of Sciences of the United States of America 100, 6646-51. PMID: 12738885 4. Zhang, Z. et al. (2016) Immunity 45, 737-748. PMID: 27742543 5. Davenne, T. et al. (2020) European journal of immunology 50, 56-62. PMID: 31608988 6. van der Made, CI. et al. (2020) JAMA 324, 663-673. PMID: 32706371 7. Brown, GJ. et al. (2022) Nature 605, 349-356. PMID: 35477763 | ||||||||
| 注意事項 | For research use only. |
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