Anti-Human TLR7 Recombinant Antibody (SAA1718) (HV024013)

Name: Anti-Human TLR7 Recombinant Antibody (SAA1718)
Brand: abinScience
SKU: HV024013
Price: 196 USD
Availability: InStock

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50ug
100ug
1mg

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

HV024013

Species reactivity

Human

Applications

ELISA

Host species

Mouse

Isotype

IgG2a, kappa

Clone ID

SAA1718

Clonality

Monoclonal

Target

TLR7, Toll-like receptor 7

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q9NYK1

RRID

Anti-Human TLR7 Antibody (SAA1718) (abinScience Cat# HV024013, RRID:AB_3727479)

Form

Liquid

Storage buffer

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Background

Toll-like receptor 7 (TLR7) is a ~120 kDa protein. Endosomal receptor that plays a key role in innate and adaptive immunity. Controls host immune response against pathogens through recognition of uridine-containing single strand RNAs (ssRNAs) of viral origin or guanosine analogs. Upon binding to agonists, undergoes dimerization that brings TIR domains from the two molecules into direct contact, leading to the recruitment of TIR-containing downstream adapter MYD88 through homotypic interaction. In turn, the Myddosome signaling complex is formed involving IRAK4, IRAK1, TRAF6, TRAF3 leading to activation of downstream transcription factors NF-kappa-B and IRF7 to induce pro-inflammatory cytokines and interferons, respectively. In plasmacytoid dendritic cells, RNASET2 endonuclease cooperates with PLD3 or PLD4 5'->3' exonucleases to process RNA and release 2',3'-cyclic guanosine monophosphate (2',3'-cGMP) and cytidine-rich RNA fragments that occupy TLR7 ligand-binding pockets and trigger a signaling-competent state.

1. Diebold, SS. et al. (2004) Science (New York, N.Y.) 303, 1529-31. PMID: 14976261

2. Heinz, LX. et al. (2020) Nature 581, 316-322. PMID: 32433612

3. Lee, J. et al. (2003) Proceedings of the National Academy of Sciences of the United States of America 100, 6646-51. PMID: 12738885

4. Zhang, Z. et al. (2016) Immunity 45, 737-748. PMID: 27742543

5. Davenne, T. et al. (2020) European journal of immunology 50, 56-62. PMID: 31608988

6. van der Made, CI. et al. (2020) JAMA 324, 663-673. PMID: 32706371

7. Brown, GJ. et al. (2022) Nature 605, 349-356. PMID: 35477763

Note

For research use only.

Images

SDS-PAGE

SDS-PAGE for Anti-Human TLR7 Antibody (SAA1718)

References

Datasheet

Anti-Human TLR7 Recombinant Antibody (SAA1718).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human TLR7 Recombinant Antibody (SAA1718) (HV024013)

Overview

Images

References

Datasheet

SDS

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