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| カタログ番号 | HF954014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-TOMM70 Polyclonal Antibody (HF954014) is a rabbit polyclonal antibody detecting TOMM70 in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human TOMM70 (Leu333-Leu608). | ||||||||
| ターゲット | TOM70, Translocase of outer membrane 70 kDa subunit, Mitochondrial import receptor subunit TOM70, Mitochondrial precursor proteins import receptor, KIAA0719, TOMM70A, TOMM70, Translocase of outer mitochondrial membrane protein 70 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O94826 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Mitochondrial import receptor subunit TOM70 (TOMM70) is a ~67 kDa protein. Acts as a receptor of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex). Recognizes and mediates the translocation of mitochondrial preproteins from the cytosol into the mitochondria in a chaperone dependent manner. Mediates TBK1 and IRF3 activation induced by MAVS in response to Sendai virus infection and promotes host antiviral responses during virus infection. Upon Sendai virus infection, recruits HSP90AA1:IRF3:BAX in mitochondrion and the complex induces apoptosis. 1. Young, JC. et al. (2003) Cell 112, 41-50. PMID: 12526792 2. Li, X. et al. (2022) Science (New York, N.Y.) 375, eabi4343. PMID: 35025629 3. Liu, XY. et al. (2010) Cell research 20, 994-1011. PMID: 20628368 4. Wei, B. et al. (2015) Journal of virology 89, 3804-18. PMID: 25609812 5. Jiang, HW. et al. (2020) Cellular & molecular immunology 17, 998-1000. PMID: 32728199 | ||||||||
| 注意事項 | For research use only. |
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