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Обзор
Каталожный номерHF954014
Описание
Anti-TOMM70 Polyclonal Antibody (HF954014) is a rabbit polyclonal antibody detecting TOMM70 in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
  • ●Multi-Species — Cross-reactive for translational research.
Реактивность видовHuman, Mouse, Rat
ПримененияELISA, IHC, WB
Хозяинский видRabbit
КлоональностьPolyclonal
ИзотипIgG
Иммуноген E. coli - derived recombinant Human TOMM70 (Leu333-Leu608).
Цель TOM70, Translocase of outer membrane 70 kDa subunit, Mitochondrial import receptor subunit TOM70, Mitochondrial precursor proteins import receptor, KIAA0719, TOMM70A, TOMM70, Translocase of outer mitochondrial membrane protein 70
Очистка Purified by antigen affinity column.
Номер доступа O94826
Форма Liquid
Буфер хранения 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта
Применение Разбавление
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Устойчивость и хранение Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Фон

Mitochondrial import receptor subunit TOM70 (TOMM70) is a ~67 kDa protein. Acts as a receptor of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex). Recognizes and mediates the translocation of mitochondrial preproteins from the cytosol into the mitochondria in a chaperone dependent manner. Mediates TBK1 and IRF3 activation induced by MAVS in response to Sendai virus infection and promotes host antiviral responses during virus infection. Upon Sendai virus infection, recruits HSP90AA1:IRF3:BAX in mitochondrion and the complex induces apoptosis.

1. Young, JC. et al. (2003) Cell 112, 41-50. PMID: 12526792
2. Li, X. et al. (2022) Science (New York, N.Y.) 375, eabi4343. PMID: 35025629
3. Liu, XY. et al. (2010) Cell research 20, 994-1011. PMID: 20628368
4. Wei, B. et al. (2015) Journal of virology 89, 3804-18. PMID: 25609812
5. Jiang, HW. et al. (2020) Cellular & molecular immunology 17, 998-1000. PMID: 32728199
Примечание For research use only.
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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