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Anti-Tupaia chinensis LAMP-1/CD107a Polyclonal Antibody (ZY332014)

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Aperçu
Numéro de catalogueZY332014
Description
Anti-Tupaia chinensis CD107a/LAMP1 Polyclonal Antibody (ZY332014) is a rabbit polyclonal antibody detecting lysosome-associated membrane glycoprotein 1; LAMP1 in ELISA, IHC, WB. Suitable for Tupaia chinensis.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Reactivité des espècesTupaia chinensis (Chinese tree shrew)
ApplicationsELISA, IHC, WB
Espèce hôteRabbit
ClonalitéPolyclonal
IsotypeIgG
Immunogène E. coli - derived recombinant tupaia chinensis CD107a/LAMP1 (Met136-Met484).
Cible lysosome-associated membrane glycoprotein 1; LAMP1
Niveau d'endotoxines Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Forme Liquid
Tampon de stockage 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Informations d'utilisation du produit
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stabilité et stockage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Contexte

Lysosome-associated membrane glycoprotein 1 (CD107a/LAMP1) is a ~44 kDa protein. Lysosomal membrane glycoprotein which plays an important role in lysosome biogenesis, lysosomal pH regulation, autophagy and cholesterol homeostasis. Acts as an important regulator of lysosomal lumen pH regulation by acting as a direct inhibitor of the proton channel TMEM175, facilitating lysosomal acidification for optimal hydrolase activity. Also plays an important role in NK-cells cytotoxicity. Mechanistically, participates in cytotoxic granule movement to the cell surface and perforin trafficking to the lytic granule. In addition, protects NK-cells from degranulation-associated damage induced by their own cytotoxic granule content.

1. Zhang, J. et al. (2023) Molecular cell 83, 2524-2539.e7. PMID: 37390818
2. Peters, PJ. et al. (1991) The Journal of experimental medicine 173, 1099-109. PMID: 2022921
3. Krzewski, K. et al. (2013) Blood 121, 4672-83. PMID: 23632890
4. Cohnen, A. et al. (2013) Blood 122, 1411-8. PMID: 23847195
5. Sawada, R. et al. (1993) The Journal of biological chemistry 268, 12675-81. PMID: 7685349
Note For research use only
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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Anti-Tupaia chinensis LAMP-1/CD107a Polyclonal Antibody

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