Anti-UBA7 Polyclonal Antibody (HW373014)

Name: Anti-UBA7 Polyclonal Antibody
Brand: abinScience
SKU: HW373014
Price: 168 USD
Availability: InStock

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Spécification :

50ug
100ug

Nombre :

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SDS

Aperçu

Numéro de catalogue

HW373014

Description

Anti-UBA7 Polyclonal Antibody (HW373014) is a rabbit polyclonal antibody detecting UBA7 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Reactivité des espèces

Human

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Human UBA7 (Lys429-Val488).

Cible

D8, Ubiquitin-activating enzyme 7, UBE1L, UBA7, Ubiquitin-like modifier-activating enzyme 7, UBE2, Ubiquitin-activating enzyme E1 homolog

Purification

Purified by antigen affinity column.

Numéro d'accès

P41226

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

Ubiquitin-like modifier-activating enzyme 7 (UBA7) is a ~111 kDa protein. E1-activating enzyme that catalyzes the covalent conjugation of the ubiquitin-like protein product of ISG15 to additional interferon stimulated proteins (ISGs) as well as other cellular proteins such as P53 in a process termed protein ISGylation. Plays an essential role in antiviral immunity together with ISG15 by restricting the replication of many viruses including rabies virus, influenza virus, sindbis virus, rotavirus or human cytomegalovirus. For example, ISG15 modification of influenza A protein NS1 disrupts the association of the NS1 with importin-alpha leading to NS1 nuclear import inhibition. ISGylation of human cytomegalovirs protein UL26 regulates its stability and inhibits its activities to suppress NF-kappa-B signaling.

1. Park, JH. et al. (2016) Nature communications 7, 12513. PMID: 27545325

2. Lenschow, DJ. et al. (2005) Journal of virology 79, 13974-83. PMID: 16254333

3. Giannakopoulos, NV. et al. (2009) Journal of virology 83, 1602-10. PMID: 19073728

4. Zhao, P. et al. (2017) Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 56, 44-53. PMID: 29056542

5. Lee, MK. et al. (2018) Journal of virology 92. PMID: 29743376

6. Sarkar, R. et al. (2023) Cellular signalling 112, 110891. PMID: 37722521

7. Zhao, C. et al. (2010) Proceedings of the National Academy of Sciences of the United States of America 107, 2253-8. PMID: 20133869

8. Kim, YJ. et al. (2016) PLoS pathogens 12, e1005850. PMID: 27564865

Note

For research use only.

Images

Reférences

Fiche technique

Anti-UBA7 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Protéines Recombinantes

Anticorps

Kits d'Essai

Anti-UBA7 Polyclonal Antibody (HW373014)

Aperçu

Images

Reférences

Fiche technique

SDS