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| カタログ番号 | HW373014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-UBA7 Polyclonal Antibody (HW373014) is a rabbit polyclonal antibody detecting UBA7 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human UBA7 (Lys429-Val488). | ||||||||
| ターゲット | D8, Ubiquitin-activating enzyme 7, UBE1L, UBA7, Ubiquitin-like modifier-activating enzyme 7, UBE2, Ubiquitin-activating enzyme E1 homolog | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P41226 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Ubiquitin-like modifier-activating enzyme 7 (UBA7) is a ~111 kDa protein. E1-activating enzyme that catalyzes the covalent conjugation of the ubiquitin-like protein product of ISG15 to additional interferon stimulated proteins (ISGs) as well as other cellular proteins such as P53 in a process termed protein ISGylation. Plays an essential role in antiviral immunity together with ISG15 by restricting the replication of many viruses including rabies virus, influenza virus, sindbis virus, rotavirus or human cytomegalovirus. For example, ISG15 modification of influenza A protein NS1 disrupts the association of the NS1 with importin-alpha leading to NS1 nuclear import inhibition. ISGylation of human cytomegalovirs protein UL26 regulates its stability and inhibits its activities to suppress NF-kappa-B signaling. 1. Park, JH. et al. (2016) Nature communications 7, 12513. PMID: 27545325 2. Lenschow, DJ. et al. (2005) Journal of virology 79, 13974-83. PMID: 16254333 3. Giannakopoulos, NV. et al. (2009) Journal of virology 83, 1602-10. PMID: 19073728 4. Zhao, P. et al. (2017) Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 56, 44-53. PMID: 29056542 5. Lee, MK. et al. (2018) Journal of virology 92. PMID: 29743376 6. Sarkar, R. et al. (2023) Cellular signalling 112, 110891. PMID: 37722521 7. Zhao, C. et al. (2010) Proceedings of the National Academy of Sciences of the United States of America 107, 2253-8. PMID: 20133869 8. Kim, YJ. et al. (2016) PLoS pathogens 12, e1005850. PMID: 27564865 | ||||||||
| 注意事項 | For research use only. |
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